p.P561R Pro561Arg (p.P592R Pro592Arg in primary sequence with 31 amino-acids signal peptide) Genotyping of 48 unrelated individuals from each of four populations gave R561 allele frequency of 11.5% in Afro-Americans 39.5% in Ashkenazi Jews 33.3% in Sepharadic Jews and 33.3% in Israeli Arabs (Hasin et al 2004), Pro561Arg mature protein Pro592Arg with signal peptide (Valle et al. 2011)
