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Substrate Report for: Octanoyl-ghrelin

Name Class
Octanoyl-ghrelinTypeAcyl peptide
Other_Name (5)
Chemical_Nomenclatureoctanoyl ghrelin; [O-n-octanoyl-Ser3]-human ghrelin
Paper (13)
Structure6ZYF
CommentGhrelin is a 28 amino acid peptide hormone whose active form is esterified at Ser 3 with octanoic acid. Octanoyl-ghrelin stimulates feeding. platelet activating factor (PAF) acetylhydrolase, carboxypeptidase, cholinesterase and Notum exhibit ghrelin deacylase activity. Gastric MLTRP is a ligand for GROWTH HORMONE SECRETAGOGUE RECEPTORS. Ghrelin is widely expressed but primarily in the stomach in the adults. Ghrelin acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis. Its large precursor protein, known as appetite-regulating hormone or motilin-related peptide, contains ghrelin and obestatin. Here the InChIKey and CID are for [Des-octanoyl]-Ghrelin
Gene_locushuman-BCHE
human-NOTUM
FamilyBCHE
Pectinacetylesterase-Notum
InChIKeyBGHSOEHUOOAYMY-JTZMCQEISA-N
WikipediaGhrelin

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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