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News Report for: November-11-2020

Name Class
November-11-2020PaperMahy_2020_J.Med.Chem_63_12942
Comoletti_2020_Neuropharmacol__108381
Structure6ZVL
6ZUV
Number643
DateNovember 11, 2020
Comment Mahy et al. published that 5-Phenyl-1,3,4-oxadiazol-2(3H)-ones are potent inhibitors of Notum carboxylesterase activity identified by the optimization of a crystallographic fragment screening hit. Strutures of the Wnt deacylase Notum in complex with fragment 286 (Compound 7, 4F-329S) and with the Wnt deacylase Notum in complex with fragment 286 (Compound 7, 4F-329S) are available (6ZUV, 6ZVL) A review on: Comparative mapping of selected structural determinants on the extracellular domains of cholinesterase-like cell-adhesion molecules is published by Comoletti et al.

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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