News Report for: November-11-2020
November-11-2020 | Paper | Mahy_2020_J.Med.Chem_63_12942 |
| | Comoletti_2020_Neuropharmacol__108381 |
| Structure | 6ZVL |
| | 6ZUV |
| Number | 643 |
| Date | November 11, 2020 |
| Comment | Mahy et al. published that 5-Phenyl-1,3,4-oxadiazol-2(3H)-ones are potent inhibitors of Notum carboxylesterase activity identified by the optimization of a crystallographic fragment screening hit. Strutures of the Wnt deacylase Notum in complex with fragment 286 (Compound 7, 4F-329S) and with the Wnt deacylase Notum in complex with fragment 286 (Compound 7, 4F-329S) are available (6ZUV, 6ZVL) A review on: Comparative mapping of selected structural determinants on the extracellular domains of cholinesterase-like cell-adhesion molecules is published by Comoletti et al. |
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