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Inhibitor Report for: Nicotine

Name Class
NicotineType (7)
Other_Name (10)
Chemical_Nomenclature[-]-1-Methyl-2-[3-pyridyl]pyrrolidine
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
FormulaC10H14N2
CAS_number54-11-5
22083-74-5
MW162.2
PaperSeto_1988_Arch.Toxicol_62_37
Structure7BNE
CommentPrototype nicotinic agonist; naturally occuring isomer
Nicotine is a plant alkaloid, found in the tobacco plant, and addictive central nervous system (CNS) stimulant that causes either ganglionic stimulation in low doses or ganglionic blockage in high doses. Nicotine acts as an agonist at the nicotinic cholinergic receptors in the autonomic ganglia, at neuromuscular junctions, and in the adrenal medulla and the brain. Nicotine's CNS-stimulating activities may be mediated through the release of several neurotransmitters, including acetylcholine, beta-endorphin, dopamine, norepinephrine, serotonin, and ACTH. As a result, peripheral vasoconstriction, tachycardia, and elevated blood pressure may be observed with nicotine intake. This agent may also stimulate the chemoreceptor trigger zone, thereby inducing nausea and vomiting.
Gene_locushuman-NOTUM
CID942
89594
FamilyACHE
BCHE
Pectinacetylesterase-Notum
InChIKeySNICXCGAKADSCV-JTQLQIEISA-N
SNICXCGAKADSCV-UHFFFAOYSA-N
CanonicalSMILESCN1CCCC1C2=CN=CC=C2
InChIInChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3
IupharLig2585
WikipediaNicotine

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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