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News Report for: NOVEMBER-29-2017

Name Class
NOVEMBER-29-2017Gene_locusdugja-CHE2
dugja-CHE1
PaperHagstrom_2018_Arch.Toxicol_92_1161
Tan_2017_Nat.Commun_8_1760
Onder_2018_Anal.Chem_90_974
InhibitorMIDA-ester-4j
Number498
DateNovember 29, 2017
Comment Planarian cholinesterase: molecular and functional characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity is published by Hagstrom et al. The sequences of the two cholinesterases of Dugesia japonica are available (dugja-CHE1, dugja-CHE2). A potent selective and cell-active heteroatom-rich organoboron inhibitor (MIDA-ester-4j) of the (ox)lipid-metabolizing enzyme alpha/beta-hydrolase domain 3 (ABHD3) (human-ABHD3) is described by Tan et al. Use of (Hupresin) to capture red blood cell acetylcholinesterase for detection of soman exposure is published by Onder et al.

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