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News Report for: NOVEMBER-28-2018

Name Class
NOVEMBER-28-2018Paper (5)
Structure (9)
DateNovember 28, 2018
Comment Structural plasticity of D3-D14 ubiquitin ligase in strigolactone signalling is published by Shabek et al. and structure of Oryza sativa strigolactone esterase D14 is available (6BRT). Structural insights of stereospecific inhibition of human acetylcholinesterase by VX and subsequent reactivation by HI-6 are published by Bester et al. and structures will be available soon (6CQT, 6CQU, 6CQV, 6CQW, 6CQX, 6CQY, 6CQZ) X-ray structure and characterization of a thermostable lipase from Geobacillus thermoleovorans is published by Moharana et al. and structure is available (6A12). Two important papers on reactivation of AChE inhibited by OP are available: Reversal of tabun toxicity enabled by a triazole-annulated oxime library-reactivators of acetylcholinesterase is published by Kovarik et al. and ranks the effectiveness of these compounds in reactivating this phosphoramidate conjugate (Phosphoramidates like Tabun or some Novishoks are typically resistant to reactivation by the classic pyridinium aldoximes and their extended derivatives). The same groups published: Pharmacology, pharmacokinetics and tissue disposition of zwitterionic hydroxyaminoacetamido alkylamines as reactivating antidotes to organophosphate poisoning Sit et al..

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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