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Inhibitor Report for: N-10-Phenothiazine-2-Pyrrlidinylethyl-carbamate

N-10-Phenothiazine-2-Pyrrlidinylethyl-carbamate	Type	Phenothiazine
		Carbamate
	Other_Name	CHEMBL481153
		BDBM50292603
		2-(pyrrolidin-1-yl)ethyl 10H-phenothiazine-10-carboxylate
	Chemical_Nomenclature	2-pyrrolidin-1-ylethyl phenothiazine-10-carboxylate
	Formula	C19H20N2O2S
	MW	340.4
	Paper	Darvesh_2008_J.Med.Chem_51_4200
		Darvesh_2013_Bioorg.Med.Chem.Lett_23_3822
	Comment	(Compound 11 Darvesh et al. 2008) some Antagonist activity at muscarinic M 5-1-4 receptors histamine serotonine receptors. Ki BCHE 0.65 micro M (for comparison Donepezil 2.21 for BCHE and 0.024 for ACHE), Ka ACHE 4600 M-1min-1 (for comparison rivastigmine 1130 M-1min-1)
	CID	24841480
	Family	BCHE
	InChIKey	CJGNMVAAMQAWEF-UHFFFAOYSA-N
	CanonicalSMILES	C1CCN(C1)CCOC(=O)N2C3=CC=CC=C3SC4=CC=CC=C42
	InChI	InChI=1S/C19H20N2O2S/c22-19(23-14-13-20-11-5-6-12-20)21-15-7-1-3-9-17(15)24-18-10-4-2-8-16(18)21/h1-4,7-10H,5-6,11-14H2