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Inhibitor Report for: N-[2-(5-fluoro-1H-indol-3-yl)ethyl]acetamide

Name Class
N-[2-(5-fluoro-1H-indol-3-yl)ethyl]acetamideTypeDerivative of Tryptamine
Indole
Not A/B H target
Other_Name (5)
Chemical_NomenclatureN-[2-(5-fluoro-1H-indol-3-yl)ethyl]acetamide
FormulaC12H13FN2O
CAS_number2806-01-1
MW220.24
PaperZhao_2019_J.Pineal.Res__e12630
Zhao_2021_Future.Med.Chem__
Zhao_2022_ACS.Chem.Neurosci_13_2060
Structure6TR7
CommentNot a true inhibitor of Notum, Fragment-106 compound 8. derivative of N-Acetylserotonin where hydroxy is replaced by fluor, related to melatonin, fragment hit with poor inhibition IC50 37200 nM compound 14 in Zhao et al 2021
Gene_locushuman-NOTUM
CID699127
FamilyPectinacetylesterase-Notum
InChIKeyUDLASALUJLTGJV-UHFFFAOYSA-N
CanonicalSMILESCC(=O)NCCC1=CNC2=C1C=C(C=C2)F
InChIInChI=1S/C12H13FN2O/c1-8(16)14-5-4-9-7-15-12-3-2-10(13)6-11(9)12/h2-3,6-7,15H,4-5H2,1H3,(H,14,16)

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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