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Substrate Report for: Methylphenidate

Name Class
MethylphenidateTypePiperidine
Not A/B H target
Drug
Other_Name (11)
Chemical_Nomenclaturemethyl 2-phenyl-2-piperidin-2-ylacetate
FormulaC14H19NO2
CAS_number113-45-1
MW233.30
Paper (21)
CommentUsed alongside educational and psychosocial intervention to treat attention deficit hyperactivity disorder (ADHD) and to treat narcolepsy. This drug blocks the reuptake of norepinephrine and dopamine into presynaptic neurons, resulting in increased levels of monoamines active in the extraneuronal space. It is metabolised by Carboxylesterases. The d-MPH enantiomer is the most active
Gene_locushuman-CES1
CID4158
FamilyCarb_B_Chordata
InChIKeyDUGOZIWVEXMGBE-UHFFFAOYSA-N
CanonicalSMILESCOC(=O)C(C1CCCCN1)C2=CC=CC=C2
InChIInChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3
WikipediaMethylphenidate

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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