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News Report for: March-09-2022

Name Class
March-09-2022Paper (7)
Structure (9)
DateMarch 09, 2022
Comment Human Butyrylcholinesterase in complex with N-(2-(1H-Indol-3-yl)ethyl)-2-cycloheptyl-N-methylethan-1-amine and 3-(2-(butyl(2-cycloheptylethyl)amino)ethyl)-1H-indol-6-ol are available (7BO3, 7BO4) and 'Tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series' is published soon by Meden et al. Sun et al. published that Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model. Structure of soluble epoxide hydrolase (sEH) in complex with Kurarinone is available soon (7EBA). Crystal structure of the Geobacillus thermoglucosidasius feruloyl esterase GthFAE is available (7WWH) and tructure-guided rational design of GthFAE to improve its thermostability is published by Yang et al. Substrate-binding mode of a thermophilic PET hydrolase and engineering the enzyme to enhance the hydrolytic efficacy is published by Zeng et al. and structures of leaf-branch compost cutinase variant apo and in complex are available (7VVC, 7VVE, 7W1N, 7W44, 7W45) A new class of bi- and trifunctional sugar oximes as antidotes against organophosphorus poisoning is published by Da Silva et al. and crystal structure of human acetylcholinesterase in complex with (E)-3-hydroxy-6-(3-(4-(4-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)butyl)-1H-1,2,3-triazol-1-yl)propyl)picolinaldehyde oxime is available (7P1P) Molecular and kinetic characterization of two acetylcholinesterases with particular focus on the roles of two amino acid substitutions (Y390N and F392W) in Bemisia tabaci is published by Kim et al. Engineered HaloTag variants for fluorescence lifetime multiplexing are published Frei et al.

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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