Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: ML225

ML225	Type	Triazol
		Urea derivative
		Pyrrolidine
	Other_Name (5)
	Chemical_Nomenclature	[4-(4-phenylphenyl)triazol-2-yl]-pyrrolidin-1-ylmethanone
	Formula	C19H18N4O
	CAS_number	1361526-43-3
	MW	318.4
	Paper	Adibekian_2011_Probe.Report__2
		Adibekian_2011_Nat.Chem.Biol_7_469
	Comment	specific for human-PAFAH2IC50 = 3 nM), and is active in situ at sub-nanomolar concentrations. ML225 is at least 333-fold selective for all other serine hydrolases
	Gene_locus	human-PAFAH2
	CID	56593029
	Family	PAF-Acetylhydrolase
	InChIKey	UKVJRODNCZDEBC-UHFFFAOYSA-N
	CanonicalSMILES	C1CCN(C1)C(=O)N2N=CC(=N2)C3=CC=C(C=C3)C4=CC=CC=C4
	InChI	InChI=1S/C19H18N4O/c24-19(22-12-4-5-13-22)23-20-14-18(21-23)17-10-8-16(9-11-17)15-6-2-1-3-7-15/h1-3,6-11,14H,4-5,12-13H2