We are very pleased to wish a Happy Birthday to 'Alex' (Alexander Karczmar), a fine, young at heart and spirit 'cholinergiker', who turned 100 this week! For those of you who did not get a chance of meeting the great mentor follow these links: Link1, Link2 and to see nice pictures of Alex with some of us, this link: Link3. The latest Newsletter is available Newsletter8. Demonstration of a conformational switch in PhaZ7 PHB depolymerase is published by Kellici et al. and structures are available (5MLX, 5MLY) Demonstration that human alpha beta hydrolase domain containing protein 11 and its yeast homolog are lipid hydrolases is published by Arya et al. A new family of protein was introduced ABHD11-Acetyl_transferase. A new complex homozygous mutation in ABHD12 responsible for PHARC syndrome is published by Lerat et al.