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Inhibitor Report for: M30D

Name Class
M30DType (4)
Other_NameProchelators, 2
SCHEMBL608520
CHEMBL3407591
BDBM36552
Chemical_Nomenclature[5-[[methyl(prop-2-ynyl)amino]methyl]quinolin-8-yl] N,N-dimethylcarbamate
FormulaC17H19N3O2
MW297.35
PaperZheng_2010_Neurochem.Res_35_2117
Mehta_2012_Int.J.Alzheimers.Dis_2012_728983
Zheng_2012_J.Alzheimers.Dis_30_1
Youdim_2006_Curr.Alzheimer.Res_3_541
CommentM30D was constructed using the key pharmacophoric moieties from rasagiline (MAOI), rivastigmine, and tacrine. The carbamyl group is cleaved by AChE to release M30D that binds to metal ions to block free radical production
Gene_locushuman-ACHE
CID46863225
FamilyACHE
InChIKeyJWUFDSSCTMPGLI-UHFFFAOYSA-N
CanonicalSMILESCN(C)C(=O)OC1=C2C(=C(C=C1)CN(C)CC#C)C=CC=N2
InChIInChI=1S/C17H19N3O2/c1-5-11-20(4)12-13-8-9-15(22-17(21)19(2)3)16-14(13)7-6-10-18-16/h1,6-10H,11-12H2,2-4H3

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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