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Inhibitor Report for: M30D

M30D	Type	Monoamine-oxidase-inhibitor
		Multitarget
		Carbamate
		Quinoline
	Other_Name (4)
	Chemical_Nomenclature	[5-[[methyl(prop-2-ynyl)amino]methyl]quinolin-8-yl] N,N-dimethylcarbamate
	Formula	C17H19N3O2
	MW	297.35
	Paper	Zheng_2010_Neurochem.Res_35_2117
		Mehta_2012_Int.J.Alzheimers.Dis_2012_728983
		Zheng_2012_J.Alzheimers.Dis_30_1
	Comment	M30D was constructed using the key pharmacophoric moieties from rasagiline (MAOI), rivastigmine, and tacrine. The carbamyl group is cleaved by AChE to release M30D that binds to metal ions to block free radical production
	Gene_locus	human-ACHE
	CID	46863225
	Family	ACHE
	InChIKey	JWUFDSSCTMPGLI-UHFFFAOYSA-N
	CanonicalSMILES	CN(C)C(=O)OC1=C2C(=C(C=C1)CN(C)CC#C)C=CC=N2
	InChI	InChI=1S/C17H19N3O2/c1-5-11-20(4)12-13-8-9-15(22-17(21)19(2)3)16-14(13)7-6-10-18-16/h1,6-10H,11-12H2,2-4H3