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News Report for: JUNE-26-2019

Name Class
JUNE-26-2019Paper (6)
Structure (11)
Number574
DateJune 26, 2019
CommentThe evolution of the canonical nucleophile/His/Asp catalytic triad of the hydrolases to an Ala/His/Asp triad is favorable for catalyzing dioxygenolytic PQS ring cleavage in cofactor-less dioxygenase AqdC of Mycobacteroides abscessus is published by Wullich et al. and structures of AqdC in its native state and in complex with the PQS cleavage product N-octanoylanthranilic acid, and of mutant AqdC proteins in complex with PQS will be available soon (6RA2, 6RA3, 6RB3) The critical role of plastid lipase PLIP1 for seed viability in diacylglycerol acyltransferase 1 mutant seed is published by Aulakh et al. Elevated levels of arachidonic acid-derived lipids including prostaglandins and endocannabinoids are present throughout ABHD12 knockout brains is published by Leishman et al. Cholesterol-lowering effects of the beta-blocker talinolol works by inhibition of the enzyme soluble epoxide hydrolase (sEH) is analyzed by X-Ray structure (Hiesinger et al.). Morpholino-talinolol exhibited in vivo activity in a rat model of diabetic neuropatic pain. Structures will be available soon (6HGX, 6HGV, 6HGW) Chemical synthesis and characterization of a new quinazolinedione competitive antagonist for strigolactone receptors with an unexpected binding mode are published by Hamiaux et al. and structure is available (6O5J) Substrate-based allosteric regulation of a homodimeric enzyme: fluoroacetate dehalogenase is published by Mehrabi et al. and structures are available (6QKS, 6QKT, 6QKU, 6QKW)

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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