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News Report for: JULY-03-2019

Name Class
JULY-03-2019PaperChaloupkova_2019_ACS.Catal_9_48103
Hiesinger_2019_ACS.Med.Chem.Lett_10_899
Wullich_2019_J.Struct.Biol_207_287
Structure (5)
Number575
DateJuly 03, 2019
Comment Crystal structure of the common ancestor of haloalkane dehalogenases and Renilla luciferase (AncHLD-RLuc) is available (6G75) and is published by Chaloupkova et al. . Cholesterol-lowering effects of the beta-blocker talinolol works by inhibition of the enzyme soluble epoxide hydrolase (sEH) is analyzed by X-Ray structure (Hiesinger et al.). Morpholino-talinolol exhibited in vivo activity in a rat model of diabetic neuropatic pain. Structures are available (6HGX, 6HGV) The evolution of the canonical nucleophile/His/Asp catalytic triad of the hydrolases to an Ala/His/Asp triad is favorable for catalyzing dioxygenolytic PQS ring cleavage in cofactor-less dioxygenase AqdC of Mycobacteroides abscessus is published by Wullich et al. and structures of AqdC in its native state and in complex with the PQS cleavage product N-octanoylanthranilic acid, and of mutant AqdC proteins in complex with PQS are available (6RA2, 6RA3, 6RB3)

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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