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Inhibitor Report for: JMN4

JMN4	Type	Piperazine
		Quinoline
	Other_Name (5)
	Chemical_Nomenclature	(4-phenylphenyl) 4-(2-methylquinolin-4-yl)piperazine-1-carboxylate
	Formula	C27H25N3O2
	MW	423.5
	Paper	Nagano_2013_Bioorg.Med.Chem.Lett_23_839
	Comment	JMN4 exhibited superior potency for inhibiting recombinant mouse (IC50 = 90 nM) and human (IC50 = 5.9 nM) Lp-PLA2 compared to either WWL153 (IC50 = 290 nM for mouse Lp-PLA2; IC50 = 250 nM for human Lp-PLA2) or P9 (IC50 = 470 nM for mouse Lp-PLA2; IC50 = 100 nM for human Lp-PLA2)
	Gene_locus	human-PLA2G7
	CID	53364494
	Family	PAF-Acetylhydrolase
	InChIKey	VJMDOENKGACNEX-UHFFFAOYSA-N
	CanonicalSMILES	CC1=NC2=CC=CC=C2C(=C1)N3CCN(CC3)C(=O)OC4=CC=C(C=C4)C5=CC=CC=C5
	InChI	InChI=1S/C27H25N3O2/c1-20-19-26(24-9-5-6-10-25(24)28-20)29-15-17-30(18-16-29)27(31)32-23-13-11-22(12-14-23)21-7-3-2-4-8-21/h2-14,19H,15-18H2,1H3