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News Report for: JANUARY-21-2016

Name Class
JANUARY-21-2016Paper (5)
Structure (16)
DateJanuary 21, 2016
CommentThe 15th International Symposium on Cholinergic Mechanisms is now scheduled for October 16-20th, 2016, Marseille, France (XVth ISCM). Visualizing the mechanism of epoxide hydrolysis by the bacterial virulence enzyme Cif is published by Bahl et al. and structures of mutants with substrate, covalent intermediate or product are available (4DMC, 4DNF, 4EHB, 4DNO, 4EUS). Structures of an acetylester hydrolase from Corynebacterium glutamicum (5D7B, 5D6O) and of the acetyl esterase MekB (5EFZ, 5E4Y) are available and define a new family of bacterial enzymes homologous to L-homoserine O-acetyl transferases (Homoserine_transacetylase_like_est). This new family is published by Toelzer et al... Steric and dynamic parameters influencing in situ cycloadditions to form triazole inhibitors with crystalline acetylcholinesterase are published by Bourne et al. and structures (5EHN, 5EHQ, 5EIH, 5EIA, 5EIE, 5EHZ) are available. Crystal structure of mouse acetylcholinesterase inhibited by DFP (5HCU) is available and published by Katz et al.. The Type II Secreted Lipase/Esterase LesA is a key virulence factor required for Xylella fastidiosa pathogenesis in grapevines and is published by Nascimento et al.

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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