Substrate

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Substrate Report for: Irinotecan

Name Class
IrinotecanTypeCarbamate
Drug
Derivative of Irinotecan
Other_Name (8)
Chemical_Nomenclature7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin)
FormulaC33H38N4O6
CAS_number97682-44-5
MW586.69
Paper (18)
Structure1K4Y
CommentIrinotecan (CPT-11) an anticancer prodrug is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to its active metabolite SN-38 97-ethyl-10-hydroxycamptothecin) a potent inhibitor of topoisomerase I.
CPT-11 is hydrolysed by carboxylesterases in human pig and rabbit. Horse BChE hydrolyses 200 times faster CPT-11 than human BChE
Gene_locushuman-BCHE
human-CES1
9sphn-E93
CID60838
FamilyCarb_B_Chordata
BCHE
Carb_B_Bacteria
InChIKeyUWKQSNNFCGGAFS-XIFFEERXSA-N
CanonicalSMILESCCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
InChIInChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3/t33-/m0/s1
WikipediaIrinotecan

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer