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Substrate Report for: Idalopirdine-rivastigmine

Idalopirdine-rivastigmine	Type (6)
	Formula	C21H24FN3O2
	MW	369.43
	Paper	Toublet_2020_Eur.J.Med.Chem_210_113059
	Comment	butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist. BuChE (IC50 = 0.97 microM). After hydrolysis a potent 5-HT6 receptors antagonist (Ki = 11.4 nM) related to idalopirdine is released
	Gene_locus	human-BCHE
	Family	BCHE
	InChIKey	QZGAFMLTVWNDEJ-UHFFFAOYSA-N
	CanonicalSMILES	C1(=C[N]C2=CC(=CC=C12)F)CCNCC3=CC(=CC=C3)OC(=O)N(C)CC
	InChI	InChI=1S/C21H24FN3O2/c1-3-25(2)21(26)27-18-6-4-5-15(11-18)13-23-10-9-16-14-24-20-12-17(22)7-8-19(16)20/h4-8,11-12,14,23-24H,3,9-10,13H2,1-2H3