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Inhibitor Report for: Galanthamine

Name Class
GalanthamineType (5)
Other_Name (6)
Chemical_Nomenclature1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-2methylbenzofuro[4,3,2-efg][2]benzazocin-6-ol
FormulaC17H21NO3
CAS_number357-70-0
MW287.35
Paper (45)
Structure1DX6
1QTI
1W6R
1W76
4EY6
CommentIn 1951, the Russian pharmacologist Mikhail Mashkovsky discovered that local villagers from the Urals used the wild snowdrop (Galanthus spp., most notably Galanthus woronowii Losinsk.) to stave off paralysis in children suffering from poliomyelitis. The ethnobotanical use of the snowdrop in the Urals led to the isolation of galanthamine for the first time in 1952, an alkaloid with AChE-inhibiting propertiesAlkaloid from caucasian snow-drop Galenthus woronowii, the common snowdrop Galanthus nivalis Ungernia genus, Amaryllidaceae, from Narcissus spp. Selectivity for AChE. The CAS number of Galanthamine Hydrobromide is 1953-04-4.
Nivalin Reminyl trademark approved for treatment of Alzheimer disease in Austria.
Galantamine is a specific competitive and reversible aceylcholinesterase inhibitor. It is also an allosteric modulator at nicotinic cholinergic receptor sites potentiating cholinergic nicotinic neurotransmission at the ganglionic and the neuromuscular junctions.
Gene_locustorca-ACHE
human-ACHE
CID9651
FamilyACHE
InChIKeyASUTZQLVASHGKV-JDFRZJQESA-N
CanonicalSMILESCN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O
InChIInChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1
IupharLig6693
WikipediaGalanthamine

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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