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Inhibitor Report for: Fenthion-oxon

Name Class
Fenthion-oxonTypeInsecticide
Organophosphate
Sulfur Compound
Organothiophosphate
Other_Name (10)
Chemical_Nomenclaturedimethyl (3-methyl-4-methylsulfanylphenyl) phosphate
FormulaC10H15O4PS
CAS_number6552-12-1
MW262.26
PaperLee_2020_Molecules_25_1938
Leoni_2008_Toxicol.Appl.Pharmacol_233_343
Kitamura_2000_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_126_259
Structure7P7V
CommentIn Australia and the USA, fenthion is used for agricultural purposes and to control cockroaches, crickets, flies, mosquitoes and spiders. It is also present in veterinary drug formulations to control fleas on dogs in Australia, and used as a mosquito adulticide, to control lice, flies, and ticks on cattle and swine or dragonfly larvae in aquaculture Like other organophosphotohionate pesticides fenthion is not active on AChE per se, but it has to be bioactivated: sulfoxidation to fenthion-sulfoxide (FEN-sulfoxide), catalyzed by cytochrome P450 or flavin-containing monooxygenase, and a CYP-mediated oxidative desulfuration to form fenthion-oxon
CID23046
FamilyACHE
InChIKeyZNRZGJAHNMGWQN-UHFFFAOYSA-N
CanonicalSMILESCC1=C(C=CC(=C1)OP(=O)(OC)OC)SC
InChIInChI=1S/C10H15O4PS/c1-8-7-9(5-6-10(8)16-4)14-15(11,12-2)13-3/h5-7H,1-4H3

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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