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Inhibitor Report for: FP-Desthiobiotin

Name Class
FP-DesthiobiotinTypeOrganophosphate
ABPP-Probe
Biotin derivative
Other_NameActivX Desthiobiotin-FP
ActivX DTB-FP
DTB-FP
Chemical_NomenclatureEthyl (10-(6-((4R,5S)-5-methyl-2-oxoimidazolidin-4-yl)hexanamido)decyl)phosphonofluoridate
FormulaC22H43FN3O4P
CAS_number1811556-65-6
MW463.57
PaperGoo_2014_Arterioscler.Thromb.Vasc.Biol_34_386
Dehghani_2023_J.Pharm.Sci__
Liu_2022_Anal.Chem_94_8625
CommentSerine Hydrolase probe consisting of a tag linked to a fluorophosphonate (FP) group, which specifically and covalently labels serines of enzymatically active serine hydrolases. ABPP-Probe (activity based protein profiling probe)
CID145710413
FamilyLIDHydrolase
InChIKeyAKIGUFDWVLQSPA-LVQXAQMUSA-N
CanonicalSMILESCCO[P](=O)(CCCCCCCCCCN(C(=O)CCCCC[C@@H]1[C@@H](N(C(=O)N1[H])[H])C)[H])F
InChIInChI=1S/C22H43FN3O4P/c1-3-30-31(23,29)18-14-9-7-5-4-6-8-13-17-24-21(27)16-12-10-11-15-20-19(2)25-22(28)26-20/h19-20H,3-18H2,1-2H3,(H,24,27)(H2,25,26,28)/t19-,20+,31?/m0/s1

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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