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Mutation Report for: F295L/F338A_human-ACHE

Name Class
F295L/F338A_human-ACHEGene_locushuman-ACHE
Torpedo_number331,288
331
288
AA_ChangeF295L/F338A
Mode_of_mutationSite directed mutagenesis
ModificationAcyl specificity
Summary (2)
PaperShafferman_2005_Chem.Biol.Interact_157-158_123
Cochran_2011_J.Biol.Chem_286_29718
Commentp.F295L/F338A Phe295Leu/Phe338Ala (p.F326L/F369A Phe326Leu/Phe369Ala in primary sequence with 31 amino-acids signal peptide) Acyl specificity;Acyl pocket 55-fold decreased catalytic activity, orientation of His 447

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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