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Mutation Report for: F295L/F297V/Y337A_human-ACHE

Name Class
F295L/F297V/Y337A_human-ACHEGene_locushuman-ACHE
Torpedo_number288
290
330
288,290,330
AA_ChangeF295L/F297V/Y337A
Mode_of_mutationSite directed mutagenesis
ModificationAcyl specificity
SummaryAcyl specificity;replacement of aromatic active center residues in human-ACHE by the corresponding residues in human-BCHE;Kaplan_2001_Biochemistry_40_7433;Barak_2005_Chem.Biol.Interact_157-158_219
PaperKaplan_2001_Biochemistry_40_7433
Barak_2005_Chem.Biol.Interact_157-158_219
Kinetic_parameter (6)
Commentp.F295L/F297V/Y337A Phe295Leu/Phe297Val/Tyr337Ala (p.F326L/F328V/Y368A Phe326Leu/Phe328Val/Tyr368Ala in primary sequence with 31 amino-acids signal peptide) Acyl specificity;replacement of aromatic active center residues in human-ACHE by the corresponding residues in human-BCHE
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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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