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Mutation Report for: F295A_human-ACHE

Name Class
F295A_human-ACHEGene_locushuman-ACHE
Torpedo_number288
AA_ChangeF295A
Mode_of_mutationSite directed mutagenesis
ModificationAcyl specificity
Summary (4)
Paper (11)
Kinetic_parameterAcetylthiocholine_F295A_human-ACHE
Edrophonium_F295A_human-ACHE
Hexamethonium_F295A_human-ACHE
BW284C51_F295A_human-ACHE
Propidium_F295A_human-ACHE
Decamethonium_F295A_human-ACHE
Tacrine_F295A_human-ACHE
HuperzineA_F295A_human-ACHE
Commentp.F295A Phe295Ala (p.F326A Phe326Ala in primary sequence with 31 amino-acids signal peptide) Acyl specificity;Acyl pocket, OP-specificity.inhanced affinity for BTC; increased reactivity to DFP DEFP and paraoxon, decreased catalytic activity, orientation of His 447
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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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