Mutation Report for: F295A_human-ACHE
| F295A_human-ACHE | Gene_locus | human-ACHE |
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| Torpedo_number | 288 |
| AA_Change | F295A |
| Mode_of_mutation | Site directed mutagenesis |
| Modification | Acyl specificity |
| Summary (4) |
| Paper (11) |
| Kinetic_parameter (8) |
| Comment | p.F295A Phe295Ala (p.F326A Phe326Ala in primary sequence with 31 amino-acids signal peptide) Acyl specificity;Acyl pocket, OP-specificity.inhanced affinity for BTC; increased reactivity to DFP DEFP and paraoxon, decreased catalytic activity, orientation of His 447 |
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