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Mutation Report for: F295A/F338A/V407F_human-ACHE

Name Class
F295A/F338A/V407F_human-ACHEGene_locushuman-ACHE
Torpedo_number331,288,400
331
288
400
AA_ChangeF295A/F338A/V407F
Mode_of_mutationSite directed mutagenesis
ModificationAcyl specificity
SummaryAcyl specificity;Acyl pocket only 3-fold decreased catalytic activity compensate F295A/F338A;Barak_2002_Biochemistry_41_8245;Barak_2005_Chem.Biol.Interact_157-158_219
PaperBarak_2002_Biochemistry_41_8245
Barak_2005_Chem.Biol.Interact_157-158_219
Commentp.F295A/F338A/V407F Phe295Ala/Phe338Ala/Val407Phe (p.F326A/F369A/V438F Phe326Ala/Phe369Ala/Val438Phe in primary sequence with 31 amino-acids signal peptide) Acyl pocket only 3-fold decreased catalytic activity compensate F295A/F338A

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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