Inhibitor Report for: Euphol
| Euphol | Type | Terpenoid |
|---|
| | Natural |
| Other_Name | (+)-Euphol |
| | Euphadienol |
| | CHEBI:4940 |
| | (20R)-(+)-triucalla-8,24-diene-3beta-ol |
| Chemical_Nomenclature | (3S,5R,10S,13S,14S,17S)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol |
| Formula | C30H50O |
| CAS_number | 514-47-6 |
| MW | 426.71 |
|  |
| Paper | King_2009_Chem.Biol_16_1045 |
| | Scalvini_2016_Chem.Phys.Lipids_197_13 |
| Comment | King et al. found two naturally occurring terpendoids, pristimerin and euphol. Euphol less potent than pristimerin (IC50 = 315 +/- 1 nM) but inhibits also ABHD6 (IC50 = 98 +/- 8 nM) |
| CID | 441678 |
| Family | Monoglyceridelipase_lysophospholip |
| | ABHD6-Lip |
| InChIKey | CAHGCLMLTWQZNJ-WZLOIPHISA-N |
| CanonicalSMILES | CC(CCC=C(C)C)C1CCC2(C1(CCC3=C2CCC4C3(CCC(C4(C)C)O)C)C)C |
| InChI | InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22+,25+,26+,28-,29+,30-/m1/s1 |
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