Family

Go to basket

Tree Display

AceDB Schema

XML Display

Feedback

Family Report for: Epoxide_hydrolase

Name Class
Epoxide_hydrolaseRank2
FamilyEpoxide-hydrolase_like
Gene_locus (1166)
Gene_locus_Frgt (81)
BlockX
Paper (9)
Structure (171)
EC_number3.3.2.9
3.3.2.10
InterproIPR000639 Epoxide hydrolase-like
IPR016292 Epoxide hydrolase
IPR010497 Epoxide hydrolase, N-terminal
CommentEpoxide hydrolases catalyze the conversion of epoxides to corresponding diols. The catalytic triad nucleophile is an invariable aspartate that opens the epoxide ring by nuclophile attack. The mammalian soluble EHs contain 2 evolutionarily distinct domains, the N-terminal domain is similar to bacterial haloacid dehalogenase (not related to alpha/beta-hydrolase fold), while the C-terminal domain is similar to soluble plant EH, microsomal EH, and bacterial haloalkane_dehalogenase (HLD). In InterPro IPR000639 groups Epoxide hydrolase and Haloalkane dehalogenase. IPR000639; Epoxide hydrolase contains some Carboxymethylbutenolide_lactonase (trembl Q9WWZ4) Carbon-carbon_bond_hydrolase (trembl Q98I15 Q9KH20 Q9K5C1 Q9KWQ6 Q9ZAY1 Q9ZNJ3 Q9RBF3 Q9RBT0) Monoglyceridelipase_lysophospholip (trembl Q97TG8). In ESTHER they are classified in the later sub family. (there are also epoxide hydrolases not related to a/b hydrolases ex: 1NWW limonene-1,2-epoxide hydrolase Arand et al. 2003) Zhu et al. (2003) identified compound heterozygosity for 2 mutations in the EPHX1 gene, which resulted in a significant decrease in EPHX1 promoter activity.
PfamPF06441 EHN
PF00561 Abhydrolase_1
PIRSFPIRSF001112 Epoxide_hydrolase
Inhibitor (127)
Substrate (41)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer