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Mutation Report for: E84Q_human-ACHE
Name
Class
E84Q_human-ACHE
Gene_locus
human-ACHE
Torpedo_number
82
AA_Change
E84Q
Mode_of_mutation
Site directed mutagenesis
Modification
Omega loop
Electrostatic
Summary (2)
Paper (5)
Kinetic_parameter
Acetylthiocholine_E84Q_human-ACHE
3,3-dimethylbutylthioacetate_E84Q_human-ACHE
Edrophonium_E84Q_human-ACHE
Comment
p.E84Q Glu84Gln (p.E115Q Glu115Gln in primary sequence with 31 amino-acids signal peptide) Omega loop;No effect - Electrostatic carboxyl/attraction studies Little effect on hydrolysis or inhibition
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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