ESTHER
Database
Home
Search
Text search
aql query
In Class
Query Builder
Preformed queries
Species
Structures
Mutations
Interactants
Diseases
Genes
Insecticides
Other
Full List
Queries for insecticide resistance
AQL exemples
Tools
Blast
HMMER
Clustal
Psiblast
Intra
Families
Overall Table
Tree Table &
Old Table
Tree Table
Old Table
Explore genes with AQL
Explore species with AQL
All figures of families
Biological
data
Structures
Table
Explore structure with AQL
Mutations
Mutation Viewer
Mutalign
Mutalign 2
Mutalign for insecticide resistance
Queries for insecticide resistance
Explore mutation with AQL
Interactants
Substrates
Inhibitors
Reactivators
Kinetic comparison tool
Inhibitor types
Substrate types
Reactivator types
Explore interactants with AQL
Diseases
Table
Explore disease with AQL
Basics on AChE
Kinetics notes
Gene structures
Molecular forms
AChE Family
Human AChE
ESTHER definition
What is up?
Likid
DB Explorer
Meetings
Suplementary Data
Latest modifications
Bibliography (all years)
Acknowledgments
& disclaimer
Mutation
Kinetic parameters
Tree Display
AceDB Schema
XML Display
Feedback
Mutation Report for: E84Q_human-ACHE
Name
Class
E84Q_human-ACHE
Gene_locus
human-ACHE
Torpedo_number
82
AA_Change
E84Q
Mode_of_mutation
Site directed mutagenesis
Modification (2)
Summary
Omega loop;No effect;Velan_1996_FEBS.Lett_395_22
Electrostatic;Electrostatic carboxyl/attraction studies Little effect on hydrolysis or inhibition;Shafferman_1992_J.Biol.Chem_267_17640;Shafferman_1992_4th.ChE.Meeting.Eilat__165;Kronman_1994_J.Biol.Chem_269_27819;Shafferman_1994_EMBO.J_13_3448
Paper (5)
Kinetic_parameter
Acetylthiocholine_E84Q_human-ACHE
3,3-dimethylbutylthioacetate_E84Q_human-ACHE
Edrophonium_E84Q_human-ACHE
Comment
p.E84Q Glu84Gln (p.E115Q Glu115Gln in primary sequence with 31 amino-acids signal peptide) Omega loop;No effect - Electrostatic carboxyl/attraction studies Little effect on hydrolysis or inhibition
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page
and
ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster
Acknowledgements and disclaimer