Mutation Report for: E84Q_human-ACHE

E84Q_human-ACHE	Gene_locus	human-ACHE
	Torpedo_number	82
	AA_Change	E84Q
	Mode_of_mutation	Site directed mutagenesis
	Modification (2)
	Summary	Omega loop;No effect;Velan_1996_FEBS.Lett_395_22
		Electrostatic;Electrostatic carboxyl/attraction studies Little effect on hydrolysis or inhibition;Shafferman_1992_J.Biol.Chem_267_17640;Shafferman_1992_4th.ChE.Meeting.Eilat__165;Kronman_1994_J.Biol.Chem_269_27819;Shafferman_1994_EMBO.J_13_3448
	Paper (5)
	Kinetic_parameter	Acetylthiocholine_E84Q_human-ACHE
		3,3-dimethylbutylthioacetate_E84Q_human-ACHE
		Edrophonium_E84Q_human-ACHE
	Comment	p.E84Q Glu84Gln (p.E115Q Glu115Gln in primary sequence with 31 amino-acids signal peptide) Omega loop;No effect - Electrostatic carboxyl/attraction studies Little effect on hydrolysis or inhibition

Send your questions or comments to :Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.

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