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Mutation Report for: E84Q/E285A/E292A/D349N/E358Q_human-ACHE

Name Class
E84Q/E285A/E292A/D349N/E358Q_human-ACHEGene_locushuman-ACHE
Torpedo_number82,278,285,342,351
351
342
285
278
82
AA_ChangeE84Q/E285A/E292A/D349N/E358Q
Mode_of_mutationSite directed mutagenesis
ModificationElectrostatic
SummaryElectrostatic;Electrostatic attraction hypothesis no significant effect;Shafferman_1994_EMBO.J_13_3448
PaperShafferman_1994_EMBO.J_13_3448
Kinetic_parameterAcetylthiocholine_E84Q/E285A/E292A/D349N/E358Q_human-ACHE
3,3-dimethylbutylthioacetate_E84Q/E285A/E292A/D349N/E358Q_human-ACHE
Edrophonium_E84Q/E285A/E292A/D349N/E358Q_human-ACHE
Commentp.E84Q/E285A/E292A/D349N/E358Q Glu84Gln/Glu285Ala/Glu292Ala/Asp349Asn/Glu358Gln (p.E115Q/E316A/E323A/D380N/E389Q Glu115Gln/Glu316Ala/Glu323Ala/Asp380Asn/Glu389Gln in primary sequence with 31 amino-acids signal peptide) Electrostatic attraction hypothesis no significant effect
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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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