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Mutation Report for: E285A/W286A_human-ACHE

Name Class
E285A/W286A_human-ACHEGene_locushuman-ACHE
Torpedo_number278,279
279
278
AA_ChangeE285A/W286A
Mode_of_mutationSite directed mutagenesis
ModificationPeripheral Anionic Site
SummaryPeripheral Anionic Site;10 to 200fold increase of inhibition K for PAS ligands;Barak_1994_J.Biol.Chem_269_6296;Shafferman_1995_5th.ChE.Meeting.Madras__189
PaperBarak_1994_J.Biol.Chem_269_6296
Shafferman_1995_5th.ChE.Meeting.Madras__189
Kinetic_parameter (6)
Commentp.E285A/W286A Glu285Ala/Trp286Ala (p.E316A/W317A Glu316Ala/Trp317Ala in primary sequence with 31 amino-acids signal peptide)Peripheral Anionic Site;10 to 200fold increase of inhibition K for PAS ligands

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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