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Mutation Report for: E202Q_mouse-ACHE
Name
Class
E202Q_mouse-ACHE
Gene_locus
mouse-ACHE
Torpedo_number
199
AA_Change
E202Q
Mode_of_mutation
Site directed mutagenesis
Modification
Electrostatic
Aging
Summary
Electrostatic;influence TFK inhibition but not ionic strength dependance;Radic_1997_J.Biol.Chem_272_23265
Aging;decreased the affinity of soman for AChE, slowed the reactivation of soman-inhibited AChE by HI-6, and decreased the aging of mutant AChE;Saxena_1997_Biochem.Pharmacol_54_269
Paper
Radic_1997_J.Biol.Chem_272_23265
Saxena_1997_Biochem.Pharmacol_54_269
Comment
p.Glu202Gln
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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