p.E202A Glu202Ala (p.E233A Glu233Ala in primary sequence with 31 amino-acids signal peptide) Catalysis;Decrease in catalytic and bimolecular constant, identical effect on charge and uncharged substrate, affects acylation-deacylation steps and not the noncovalent complex formation; H-bond network; not inhibited at high substrate concentration; Acylation,Phosphorylation;low effect on inhibition by DFP and DEFP but high for Paraoxon; Aging:E202 contributes to the aging process by stabilizing the imidazolium His447
