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Mutation Report for: E197D_human-BCHE

Name Class
E197D_human-BCHEGene_locushuman-BCHE
Torpedo_number199
AA_ChangeE197D
Mode_of_mutationSite directed mutagenesis
ModificationAging
Substrate activation
SummaryAging;Resistance to penetration of water D70 and E197 function like check valves for water;Masson_1999_Chem.Biol.Interact_119-120_17
Substrate activation;moderatly reduced substrate activation;Masson_2001_Biochim.Biophys.Acta_1544_166
Aging;E197D increases half-life of aging by DFP 5.8 times;Masson_1997_Biochem.J_327_601
PaperMasson_1997_Biochem.J_327_601
Masson_1999_Chem.Biol.Interact_119-120_17
Masson_2001_Biochim.Biophys.Acta_1544_166
Commentp.E197D Glu197Asp (p.E225D Glu225Asp in primary sequence with 28 amino-acids signal peptide) moderatly reduced substrate activation; increases half-life of aging by DFP 5.8 times
Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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