ESTHER
Database
Home
Search
Text search
aql query
In Class
Query Builder
Preformed queries
Species
Structures
Mutations
Interactants
Diseases
Genes
Insecticides
Other
Full List
Queries for insecticide resistance
AQL exemples
Tools
Blast
HMMER
Clustal
Psiblast
Intra
Families
Overall Table
Tree Table &
Old Table
Tree Table
Old Table
Explore genes with AQL
Explore species with AQL
All figures of families
Biological
data
Structures
Table
Explore structure with AQL
Mutations
Mutation Viewer
Mutalign
Mutalign 2
Mutalign for insecticide resistance
Queries for insecticide resistance
Explore mutation with AQL
Interactants
Substrates
Inhibitors
Reactivators
Kinetic comparison tool
Inhibitor types
Substrate types
Reactivator types
Explore interactants with AQL
Diseases
Table
Explore disease with AQL
Basics on AChE
Kinetics notes
Gene structures
Molecular forms
AChE Family
Human AChE
ESTHER definition
What is up?
Likid
DB Explorer
Meetings
Suplementary Data
Latest modifications
Bibliography (all years)
Acknowledgments
& disclaimer
Inhibitor
Bibliography
Biblio print
Tree Display
AceDB Schema
XML Display
Feedback
Inhibitor Report for: Donepezil-idebenone-cpd9
Name
Class
Donepezil-idebenone-cpd9
Type
Multitarget
Antioxidant
anti-Abeta-aggregation
Derivative of Donepezil
Formula
C23H24N2O2
MW
360.45
Paper
Perone_2021_ChemMedChem_16_187
Comment
multi-target-directed ligand combination therapy of donepezil and the quinone drug idebenone with antioxidant and antiaggregating properties
Gene_locus
human-BCHE
Family
BCHE
InChIKey
DDAKLCVNBJVDEK-UHFFFAOYSA-N
CanonicalSMILES
C1=CC2=C(C=C1)C(C(=C(C2=O)C)NC3CCN(CC3)CC4=CC=CC=C4)=O
InChI
InChI=1S/C23H24N2O2/c1-16-21(23(27)20-10-6-5-9-19(20)22(16)26)24-18-11-13-25(14-12-18)15-17-7-3-2-4-8-17/h2-10,18,24H,11-15H2,1H3
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page
and
ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster
Acknowledgements and disclaimer