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Substrate Report for: DTS-108

Name Class
DTS-108TypeDrug
Not A/B H target
Peptide
Other_NameSN38-BCH-CVKRGLKLRHVRP
PaperCoriat_2016_Int.J.Nanomedicine_11_6207
Meyer-Losic_2008_Clin.Cancer.Res_14_2145
CommentPeptidic prodrug of SN38 (DTS-108) is able to deliver significantly higher levels of SN38 than irinotecan, without the associated toxicity of irinotecan. DTS-108 is a cationic peptide (Vectocell) via an esterase cleavable linker
FamilyCarboxylesterase
Carb_B_Chordata

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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