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Family Report for: Cholinesterase

Name Class
CholinesteraseRank1
FamilyACHE
BCHE
Cholinesterase-like
BlockC
LED_DatabaseabH01.04
ProteopediaCholinesterase
PaperTaylor_1994_Annu.Rev.Pharmacol.Toxicol_34_281
Massoulie_2008_Chem.Biol.Interact_175_30
Massoulie_1993_Prog.Neurobiol_41_31
Chatonnet_1989_Biochem.J_260_625
InterproIPR000997 Cholinesterase
IPR002018 Carboxylesterase, type B
CommentAcetylcholinesterase (ACHE; EC 3.1.1.7) controls synaptic and neurohumoral cholinergic activity by hydrolyzing the neurotransmitter acetylcholine. ACHE function relies on precise regulation of its expression and localization. In particular, alternative splicing of the 3-prime region of ACHE results in ACHE isoforms with distinct C-terminal peptides that determine posttranslational maturation and oligomeric assembly
PfamPF00135 COesterase
PIRSFPIRSF005676 COesterase
PrintsPR00878
Inhibitor (7)
SubstrateAcetylcholine
Acetylthiocholine
O-Nitrophenylacetate

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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