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Family Report for: Cholesterol_esterase

Name Class
Cholesterol_esteraseRank2
FamilyCarboxylesterase
Gene_locus (128)
Gene_locus_Frgt (65)
BlockC
PrositePS00122
PS00941
LED_DatabaseabH01.03
WikipediaBile salt-dependent lipase
PdocPDOC00112
PaperHolmes_2011_Cholesterol_2011_781643
Wang_1997_Structure_5_1209
Chen_1998_Biochemistry_37_5107
Terzyan_2000_Protein.Sci_9_1783
Moore_2001_J.Mol.Biol_312_511
Tang_2022_Front.Genet_13_909091
Structure (10)
EC_number3.1.1.13
InterproIPR002018 Carboxylesterase, type B
IPR033560 Bile salt-activated lipase BAL
CommentThe human lactating mammary gland and pancreas produce a lipolytic enzyme, carboxyl-ester lipase, earlier called bile salt-stimulated lipase. Carboxyl-ester lipase is a major component of pancreatic juice and is responsible for the hydrolysis of cholesterol esters as well as a variety of other dietary esters. The enzyme is activated when mixed with bile salts, and plays an important role in the digestion of milk fat in newborn infants. This enzyme combines properties of esterases (activity on esters soluble in water) and lipases (activity on insoluble long chain acylglycerols) Numerous repeats at the c-term excluded in ESTHER (only n-term Pfam A COesterase 1 544)
PfamPF00135 COesterase
PIRSFPIRSF005676 COesterase
Inhibitor (15)
Substrate (13)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
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