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Family Report for: Carboxypeptidase_S10

Name Class
Carboxypeptidase_S10Rank1
Gene_locus (619)
Gene_locus_Frgt (87)
BlockX
PrositePS00131
PS00560
PdocPDOC00122
Paper (21)
Structure (20)
EC_number3.4.16.6
4.1.2.11
InterproIPR001563 Peptidase S10, serine carboxypeptidase
CommentSerine carboxypeptidase-like (SCPL) proteins. Structures determined for wheat and yeast peptidase first. Very successful family in plants (arabdopsis) also human protective protein cathepsineA. The protective protein human-CTSA is a glycoprotein that associates with lysosomal beta-galactosidase and neuraminidase and is deficient in the autosomal recessive disorder Galactosialidosis . Also contains non peptidase sequences as hydroxynitril lyase from plants. But new structure of sorghum hnl shows clear differences in catalytic mechanism because of a deletion of two amino acid adjescent of the active site serine: see sorbi-hnl and 1GXS Lauble et al 2002. It does not accept aliphatic hydroxynitriles, unlike EC 4.1.2.10 mandelonitrile lyase and EC 4.1.2.39 hydroxynitrilase. Other hydroxynitril lyase belong to another family: Hydroxynitrile_lyase . This Carboxypeptidase family also contains acyltransferases as sinapoyltransferase AT2G22990 arath-SCP8 SNG1 gene. Another enzyme, related to the SCPL family, is glucose acyltransferase from Lycopersicon pennellii catalysing the formation of diacylglucose. Some of these SCPL have a T instead of the serine in the catalytic triad: probably no catalytic activity but partner of another Serine carboxypeptitase-like protein.
PfamPF00450 Peptidase_S10
PrintsPR00724
MEROPSS10
Inhibitor (16)
Substrate (4)

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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