Family Report for: Carboxypeptidase_S10
Carboxypeptidase_S10 | Rank | 1 |
| Gene_locus (619) |
| Gene_locus_Frgt (87) |
| Block | X |
| |
| Prosite | PS00131 |
| | PS00560 |
| Pdoc | PDOC00122 |
| Paper (21) |
| Structure (20) |
| EC_number | 3.4.16.6 |
| | 4.1.2.11 |
| Interpro | IPR001563 Peptidase S10, serine carboxypeptidase |
| Comment | Serine carboxypeptidase-like (SCPL) proteins. Structures determined for wheat and yeast peptidase first. Very successful family in plants (arabdopsis) also human protective protein cathepsineA. The protective protein human-CTSA is a glycoprotein that associates with lysosomal beta-galactosidase and neuraminidase and is deficient in the autosomal recessive disorder Galactosialidosis . Also contains non peptidase sequences as hydroxynitril lyase from plants. But new structure of sorghum hnl shows clear differences in catalytic mechanism because of a deletion of two amino acid adjescent of the active site serine: see sorbi-hnl and 1GXS Lauble et al 2002. It does not accept aliphatic hydroxynitriles, unlike EC 4.1.2.10 mandelonitrile lyase and EC 4.1.2.39 hydroxynitrilase. Other hydroxynitril lyase belong to another family: Hydroxynitrile_lyase . This Carboxypeptidase family also contains acyltransferases as sinapoyltransferase AT2G22990 arath-SCP8 SNG1 gene. Another enzyme, related to the SCPL family, is glucose acyltransferase from Lycopersicon pennellii catalysing the formation of diacylglucose. Some of these SCPL have a T instead of the serine in the catalytic triad: probably no catalytic activity but partner of another Serine carboxypeptitase-like protein. |
| Pfam | PF00450 Peptidase_S10 |
| Prints | PR00724 |
| MEROPS | S10 |
| Inhibitor (16) |
| Substrate (4) |
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