Type Reactivator

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Type_reactivator Report for: Bispyridinium

Name Class
BispyridiniumReactivator (45)
CommentPyridinium refers to the cation [C5H5NH]+. Often present in oximes as in the first reactivator of OP inhibited cholinesterase Pralidoxime (2-PAM). These are charged oximes which poorly cross the blood brain barrier. When two pyridinium molecules are joined by an appropriate linker one could bind to the PAS and the other attach the phosphorus of OP inhibited cholinesterase and eventually reactivate the enzyme

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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