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Inhibitor Report for: BisQ

Name Class
BisQType (6)
Other_Name4,4'-Bis(trimethylaminiomethyl)azobenzene
Chemical_Nomenclaturetrimethyl-[[4-[[4-[(trimethylazaniumyl)methyl]phenyl]diazenyl]phenyl]methyl]azanium
FormulaC20H30N4+2
MW326.5
PaperBroichhagen_2014_Angew.Chem.Int.Ed.Engl_53_7657
Bartels_1971_Proc.Natl.Acad.Sci.U.S.A_68_1820
Lester_1982_Annu.Rev.Biophys.Bioeng_11_151
Lester_1980_Ann.N.Y.Acad.Sci_346_475
CommentPhotoswitchable agonist of the nicotinic acetylcholine receptor developped by Ehrlanger and Lester( trans most active form). BisQ is a poor inhibitor of AChE Ki 3129.3+/-1181.4 nM. Has no photodependent effect on AChE activity
Gene_locushuman-ACHE
CID14895427
133795
123131939
FamilyACHE
InChIKeyBUBUVNULLZBOQS-UHFFFAOYSA-N
CanonicalSMILESC[N+](C)(C)CC1=CC=C(C=C1)N=NC2=CC=C(C=C2)C[N+](C)(C)C
InChIInChI=1S/C20H30N4/c1-23(2,3)15-17-7-11-19(12-8-17)21-22-20-13-9-18(10-14-20)16-24(4,5)6/h7-14H,15-16H2,1-6H3/q+2

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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