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Inhibitor Report for: BisQ
Name
Class
BisQ
Type (6)
Other_Name
4,4'-Bis(trimethylaminiomethyl)azobenzene
Chemical_Nomenclature
trimethyl-[[4-[[4-[(trimethylazaniumyl)methyl]phenyl]diazenyl]phenyl]methyl]azanium
Formula
C20H30N4+2
MW
326.5
Paper
Broichhagen_2014_Angew.Chem.Int.Ed.Engl_53_7657
Bartels_1971_Proc.Natl.Acad.Sci.U.S.A_68_1820
Lester_1982_Annu.Rev.Biophys.Bioeng_11_151
Lester_1980_Ann.N.Y.Acad.Sci_346_475
Comment
Photoswitchable agonist of the nicotinic acetylcholine receptor developped by Ehrlanger and Lester( trans most active form). BisQ is a poor inhibitor of AChE Ki 3129.3+/-1181.4 nM. Has no photodependent effect on AChE activity
Gene_locus
human-ACHE
CID
14895427
133795
123131939
Family
ACHE
InChIKey
BUBUVNULLZBOQS-UHFFFAOYSA-N
CanonicalSMILES
C[N+](C)(C)CC1=CC=C(C=C1)N=NC2=CC=C(C=C2)C[N+](C)(C)C
InChI
InChI=1S/C20H30N4/c1-23(2,3)15-17-7-11-19(12-8-17)21-22-20-13-9-18(10-14-20)16-24(4,5)6/h7-14H,15-16H2,1-6H3/q+2
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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