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News Report for: August-11-2021

Name Class
August-11-2021PaperIkeda_2021_J.Med.Chem__
Tian_2021_J.Neurosci__
Chen_2021_Angew.Chem.Int.Ed.Engl_60_21959
Gautheron_2021_Elife_10_
Structure (5)
Number680
DateAugust 11, 2021
Comment Design and synthesis of novel spiro derivatives as potent and reversible Monoacylglycerol Lipase (MAGL) inhibitors: Bioisosteric transformation from 3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl moiety is published by Ikeda et al. and structures are available (7L4W, 7L50, 7L4U, 7L4T). Autism spectrum disorder/intellectual disability-associated mutations in Trio disrupt Neuroligin 1-mediated synaptogenesis is published by Tian et al. Computational design and crystal structure of a highly efficient benzoylecgonine hydrolase is published by Chen et al. and structure will be available soon (7F65) EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence as published by Gautheron et al.

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