News Report for: August-04-2021
| August-04-2021 | Paper | Bennion_2021_Sci.Rep_11_15567 |
|---|
| | Blumenthal_2021_J.Biol.Chem__ |
| | Ross_2021_J.Appl.Crystallogr_54_895 |
| | Silva-Garcia_2020_Biorxiv__ |
| | Deo_2021_Nat.Chem.Biol_17_718 |
| | Hartmann_2021_J.Med.Chem_64_2815 |
| | Zhao_2021_J.Med.Chem_64_11354 |
| | Liu_2021_Plant.Cell__ |
| Structure (18) |
| Number | 679 |
| Date | August 04, 2021 |
| Comment |  Crystal structures of DPP8 in complex with the EIL peptide (SLRFLFEGQRIADNH) and 1G244 are available (6TRW, 6TRX) and are published by Ross et al.  Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair is published by Silva-Garcia et al. and structures are available (6QZW, (6QZV) The HaloTag as a general scaffold for far-red tunable chemigenetic indicators is published by Deo et al. and structures are available (6U2M, 6U32) Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects is published by Blumenthal et al. and electro microscopy structures are available. Development of a CNS-permeable reactivator (LLNL-02) for nerve agent exposure: an iterative, multi-disciplinary approach is published by Bennion et al. Combined cardioprotective and adipocyte browning effects promoted by the eutomer of dual sEH/PPARgamma modulator TK90 is published by Hartmann et al. and structure of soluble epoxide hydrolase in complex with TK90 is available (7A7G). Novel class of covalent Notum inhibitors, 4-(indolin-1-yl)-4-oxobutanoate esters are published by Zhao et al. and structures (7ARG, 7B2Z, 7B2Y, 7B2V, 7B37, 7B3F) are available X-Ray structures of the Haloalkane dehalogenase HaloTag7 mutants labeled with fluorophore substrate are available (6ZVU, 6ZVU, 6ZVV, 6ZVX, 6ZVY) and will be published soon by Tarnawski et al. An ABHD17-like hydrolase screening system to identify de-S-acylation enzymes of protein substrates in plant cells is published by y Liu et al. |
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