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Inhibitor Report for: Atglistatin

Name Class
AtglistatinTypeUrea derivative
Biphenyl
Other_Name3-(4'-(Dimethylamino)-[1,1'-biphenyl]-3-yl)-1,1-dimethylurea
SCHEMBL15186954
AOB2795
MolPort-035-395-866
Chemical_Nomenclature3-[3-[4-(dimethylamino)phenyl]phenyl]-1,1-dimethylurea
FormulaC17H21N3O
CAS_number1469924-27-3
MW283.36
PaperIglesias_2016_J.Lipid.Res_57_131
Mayer_2013_Nat.Chem.Biol_9_785
Fang_2022_Proc.Natl.Acad.Sci.U.S.A_119_e2208855119
CommentSpecfic inhibitor of ATGL (Adipose Triglycerid lipase PNPLA2 Patatin-like phospholipase:not an alpha/beta hydrolase) Mayer et al. but inhibits also partially CES1 Iglesias et al 2016. ATGListatin inhibited mouse ATGL but not human ATG
CID71699712
FamilyCarb_B_Chordata
InChIKeyAWOPBSAJHCUSAS-UHFFFAOYSA-N
CanonicalSMILESCN(C)C1=CC=C(C=C1)C2=CC(=CC=C2)NC(=O)N(C)C
InChIInChI=1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21)

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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