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Inhibitor Report for: Aricept~Donepezil~E2020

Name Class
Aricept~Donepezil~E2020TypeDerivative of Donepezil
Piperidine
Drug
Inden
Other_Name (9)
Chemical_Nomenclature2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride
FormulaC24H30ClNO3
CAS_number (2)
MW415.953
PaperRedman_2022_Br.J.Pharmacol__
Zhang_2018_Clin.Interv.Aging_13_1963
Alagiakrishnan_2000_Hawaii.Med.J_59_57
Xu_1999_Zhongguo.Yao.Li.Xue.Bao_20_486
Camps_2000_Mol.Pharmacol_57_409
Geldmacher_1997_Compr.Ther_23_492
Gray_1997_Bmj_314_1555
Kryger_1998_J.Physiol.Paris_92_191
Kryger_1999_Structure_7_297
Ogura_2000_Nihon.Yakurigaku.Zasshi_115_45
Rogers_1998_Arch.Intern.Med_158_1021
Ross_1998_J.Am.Geriatr.Soc_46_119
Wagner_1997_Bmj_314_1555
Whitehouse_1997_Hastings.Cent.Rep_27_14
Kosasa_2000_Eur.J.Pharmacol_389_173
McGuffey_1997_J.Am.Pharm.Assoc_3_347
Rogers_1998_Neurology_50_136
Giacobini_1998_Neurochem.Int_32_413
Lopez-Pousa_1999_Neurologia_14_180
Weiner_2000_J.Clin.Psychiatry_61_487
Sugimoto_2000_Curr.Med.Chem_7_303
Ogura_2000_Methods.Find.Exp.Clin.Pharmacol_22_89
Ogura_2000_Methods.Find.Exp.Clin.Pharmacol_22_609
Cummings_2000_Am.J.Geriatr.Psychiatry_8_134
Jann_2000_Pharmacotherapy_20_1
Kaur_2000_Curr.Med.Chem_7_273
Sugimoto_1995_J.Med.Chem_38_4821
Rogers_1996_Dementia_7_293
Cheng_1996_Neuroreport_8_97
Bryson_1997_Drugs.Aging_10_234
Anderson_1997_Psychopharmacology.(Berl)_132_135
Rupniak_1997_Psychopharmacology_131_406
Kojima_1997_Methods.Find.Exp.Clin.Pharmacol_19_245
Tsukada_1997_J.Pharmacol.Exp.Ther_281_1408
Dawson_1993_Behav.Brain.Res_57_143
Doody_1999_Gerontology_45_23
Pang_1994_J.Comput.Aided.Mol.Des_8_683
Nochi_1995_Biol.Pharm.Bull_18_1145
Inoue_1996_J.Med.Chem_39_4460
Galli_1994_Eur.J.Pharmacol_270_189
Matsui_1995_J.Chromatogr.A_694_209
Boothby_1997_BMJ_315_1624
Jones_1997_BMJ_315_1624
Wilkinson_1997_BMJ_315_1625
Rogers_1998_Eur.Neuropsychopharmacol_8_67
Barner_1998_Ann.Pharmacother_32_70
Taverni_1998_Brain.Inj_12_77
Collier_1998_Bmj_316_1092
Hasegawa_1998_Neurobiol.Aging_19_S107
Cheng_1998_Pharmacol.Biochem.Behav_60_377
Svensson_1998_Neuroreport_9_1519
Costagli_1998_Biochem.Pharmacol_55_1733
Wang_1998_Eur.J.Pharmacol_349_137
Homma_2016_J.Alzheimers.Dis_52_345
Bartolini_2003_Biochem.Pharmacol_65_407
Cheung_2012_J.Med.Chem_55_10282
Structure1EVE
7E3H
6O4W
4EY7
Theoretical_model3ACE
4ACE
CommentTreatment of Alzheimer Disease, trademark is Aricept
Reversible inhibitor of AChE but not of BChE
Gene_locus (2)
CID5741
3152
FamilyACHE
InChIKeyXWAIAVWHZJNZQQ-UHFFFAOYSA-N
CanonicalSMILESCOC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
InChIInChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H
IupharLig6599
WikipediaDonepezil

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