Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: Aricept~Donepezil~E2020

Aricept~Donepezil~E2020	Type	Derivative of Donepezil
		Piperidine
		Drug
		Inden
	Other_Name (9)
	Chemical_Nomenclature	2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride
	Formula	C24H30ClNO3
	CAS_number (2)
	MW	415.953
	Paper	Zhang_2018_Clin.Interv.Aging_13_1963
		Alagiakrishnan_2000_Hawaii.Med.J_59_57
		Xu_1999_Zhongguo.Yao.Li.Xue.Bao_20_486
		Camps_2000_Mol.Pharmacol_57_409
		Geldmacher_1997_Compr.Ther_23_492
		Gray_1997_Bmj_314_1555
		Kryger_1998_J.Physiol.Paris_92_191
		Kryger_1999_Structure_7_297
		Ogura_2000_Nihon.Yakurigaku.Zasshi_115_45
		Rogers_1998_Arch.Intern.Med_158_1021
		Ross_1998_J.Am.Geriatr.Soc_46_119
		Wagner_1997_Bmj_314_1555
		Whitehouse_1997_Hastings.Cent.Rep_27_14
		Kosasa_2000_Eur.J.Pharmacol_389_173
		McGuffey_1997_J.Am.Pharm.Assoc_3_347
		Rogers_1998_Neurology_50_136
		Giacobini_1998_Neurochem.Int_32_413
		Lopez-Pousa_1999_Neurologia_14_180
		Weiner_2000_J.Clin.Psychiatry_61_487
		Sugimoto_2000_Curr.Med.Chem_7_303
		Ogura_2000_Methods.Find.Exp.Clin.Pharmacol_22_89
		Ogura_2000_Methods.Find.Exp.Clin.Pharmacol_22_609
		Cummings_2000_Am.J.Geriatr.Psychiatry_8_134
		Jann_2000_Pharmacotherapy_20_1
		Kaur_2000_Curr.Med.Chem_7_273
		Sugimoto_1995_J.Med.Chem_38_4821
		Rogers_1996_Dementia_7_293
		Cheng_1996_Neuroreport_8_97
		Bryson_1997_Drugs.Aging_10_234
		Anderson_1997_Psychopharmacology.(Berl)_132_135
		Rupniak_1997_Psychopharmacology_131_406
		Kojima_1997_Methods.Find.Exp.Clin.Pharmacol_19_245
		Tsukada_1997_J.Pharmacol.Exp.Ther_281_1408
		Dawson_1993_Behav.Brain.Res_57_143
		Doody_1999_Gerontology_45_23
		Pang_1994_J.Comput.Aided.Mol.Des_8_683
		Nochi_1995_Biol.Pharm.Bull_18_1145
		Inoue_1996_J.Med.Chem_39_4460
		Galli_1994_Eur.J.Pharmacol_270_189
		Matsui_1995_J.Chromatogr.A_694_209
		Boothby_1997_BMJ_315_1624
		Jones_1997_BMJ_315_1624
		Wilkinson_1997_BMJ_315_1625
		Rogers_1998_Eur.Neuropsychopharmacol_8_67
		Barner_1998_Ann.Pharmacother_32_70
		Taverni_1998_Brain.Inj_12_77
		Collier_1998_Bmj_316_1092
		Hasegawa_1998_Neurobiol.Aging_19_S107
		Cheng_1998_Pharmacol.Biochem.Behav_60_377
		Svensson_1998_Neuroreport_9_1519
		Costagli_1998_Biochem.Pharmacol_55_1733
		Wang_1998_Eur.J.Pharmacol_349_137
		Homma_2016_J.Alzheimers.Dis_52_345
		Bartolini_2003_Biochem.Pharmacol_65_407
	Structure	1EVE
		7E3H
		6O4W
		4EY7
	Theoretical_model	3ACE
		4ACE
	Comment	Treatment of Alzheimer Disease, trademark is Aricept
		Reversible inhibitor of AChE but not of BChE
	Gene_locus	torca-ACHE
		human-ACHE
	CID	5741
		3152
	Family	ACHE
	InChIKey	XWAIAVWHZJNZQQ-UHFFFAOYSA-N
	CanonicalSMILES	COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
	InChI	InChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H
	IupharLig	6599
	Wikipedia	Donepezil