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Inhibitor Report for: Amodiaquine

Amodiaquine	Type	Quinoline
		Not A/B H target
		Drug
	Other_Name (6)
	Chemical_Nomenclature	4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol
	Formula	C20H22ClN3O
	CAS_number	86-42-0
	MW	355.86
	Paper	Bierwisch_2016_Toxicol.Lett_246_49
		Katz_2018_Toxicol.Lett_291_1
	Comment	Amodiaquine is an orally active 4-aminoquinoline used for the therapy of malaria effective against some chloroquine-resistant strains of Plasmodium falciparum It is likely able to inhibit heme polymerase. Amodiaquine has been linked to severe cases of acute hepatitis and used only as treatment and not for prophylaxis against malaria. Amodiaquine shows mixed competitive-non-competitive inhibition type of AChE and shows slow and partial reactivation of sarin-, cyclosarin- and VX-inhibited cholinesterases. However it failed to reactivate tabun-inhibited human cholinesterases
	CID	2165
	Family	ACHE
	InChIKey	OVCDSSHSILBFBN-UHFFFAOYSA-N
	CanonicalSMILES	CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O
	InChI	InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23)